The Modified Pills-in-the-Pocket Strategy -The Combined Effect of Amiodarone, Bisoprolol and Digoxin in the Treatment of Recurrent Atrial Arrhythmia for Non-Paroxysmal Atrial Fibrillation After Catheter Ablation: A Multicenter, Prospective, Randomized, Open-Label, Blinded Endpoint Clinical Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a multicentre, prospective, randomised controlled study of 328 patients with non-paroxysmal AF (within 5 years of first diagnosis of AF) with recurrent atrial arrhythmias after first catheter ablation, randomly divided in a 1:1 ratio into a study group treated with triple AADs (amiodarone + bisoprolol + digoxin) and a control group treated with conventional AADs (amiodarone + bisoprolol + digoxin). The study group was treated with triple AADs (amiodarone + bisoprolol) and the control group was treated with conventional AADs (amiodarone + bisoprolol) with the aim of comparing the efficacy and safety of the two groups in terms of reversion of SR, which may provide an effective option of pocket drug reversion for patients with recurrence of SR after AF catheter ablation. Translated with DeepL.com (free version)

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
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Locations
Other Locations
China
Guangdong Provincial People's Hospital
RECRUITING
Guangzhou
Contact Information
Primary
Yumei Xue, phD
xymgdci@163.com
13570082363
Time Frame
Start Date: 2024-10-23
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 328
Treatments
Experimental: experimental group
use Amiodarone, Bisoprolol and Digoxin
Active_comparator: control group
use Bisoprolol and Digoxin
Related Therapeutic Areas
Sponsors
Collaborators: Beijing Anzhen Hospital, Jiangmen Central Hospital, Nanfang Hospital, Southern Medical University, The First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital, Sun Yat-Sen University, Yan 'an Hospital of Kunming City, Xiamen Cardiovascular Hospital, Sir Run Run Shaw Hospital, Zhongshan People's Hospital, Guangdong, China
Leads: Yumei Xue

This content was sourced from clinicaltrials.gov